Response to “The “gatekeeper” hypothesis challenged in a human cervico-vaginal tissue model for HIV-1 transmission”
نویسندگان
چکیده
منابع مشابه
Interleukin-7 Facilitates HIV-1 Transmission to Cervico-Vaginal Tissue ex vivo
The majority of HIV-1 infections in women occur through vaginal intercourse, in which virus-containing semen is deposited on the cervico-vaginal mucosa. Semen is more than a mere carrier of HIV-1, since it contains many biological factors, in particular cytokines, that may affect HIV-1 transmission. The concentration of interleukin (IL)-7, one of the most prominent cytokines in semen of healthy...
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Human tissue kallikrein-related peptidases (KLK) are a family of 15 genes located on chromosome 19q13.4 that encode secreted serine proteases with trypsin- and/or chymotrypsin-like activity. Relatively large levels of many KLKs are present in human cervico-vaginal fluid (CVF) and in the supernatant of cultured human vaginal epithelial cells. Many KLKs are also hormonally regulated in vaginal ep...
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Background: HSV-2, one of the most common HIV-1 copathogens, establishes a synergistic interaction with HIV-1. Several clinical trials have shown that the anti herpetic drug acyclovir decreases HIV-1 viral load and delays HIV-1 disease progression. Similarly, CAPRISA004 reported that a vaginal gel containing 1% of the anti-HIV-1 drug tenofovir unexpectedly decreases the risk of HSV-2 acquisitio...
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پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...
15 صفحه اولMarkers of local immunity in cervico-vaginal secretions of HIV infected women: implications for HIV shedding.
OBJECTIVES To link local proinflammatory cytokines with HIV related nucleic acids in cervico-vaginal secretions and the factors associated with them. METHODS An observational study on 60 HIV positive women attending the department of obstetrics and gynaecology, University of Pavia, Italy. HIV-1 RNA in plasma, proviral HIV-1-DNA, cell associated and cell free HIV-1 RNA in cervico-vaginal secre...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2010
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2010.48